From markw at illuminae.com Tue Oct 18 16:49:13 2005 From: markw at illuminae.com (Mark Wilkinson) Date: Tue Oct 18 17:20:20 2005 Subject: [MOBY-l] Migrating MOBY Central to the new object API - MONDAY OCT 24th Message-ID: <1129668553.6798.17.camel@bioinfo.icapture.ubc.ca> Hi all, Eddie and I have been discussing the object ontology migration now that we are not allowing inheritance from primitives. No matter what we do this will break some services, and though I was originally hoping to soften the blow by having a deprecation period, the amount of pain this causes (i.e. everyone having to edit and re-register their services TWICE!) is just inhumane :-) So... I am sure that some of you will cheer this decision, and others will loathe it... we're going to simply migrate the object ontology (in the public MOBY Central here at iCAPTURE) with **no deprecation period at all**. The object names will remain exactly as they are, but will (in some cases) now have different definitions. As such, for those of you running services that are affected by this change, you will only need to update your service code, but NOT need to de/re-register your service. We plan to do this Monday October 24th, so you have a few days to update your services now to reduce the down-time. The way to go about updating your services is as follows: Any XML node that currently has content, but is not a nominal primitive, will now be modified such that it CONTAINS a node that is a primitive, and that primitive will have data content. It's articleName is "content" in every case. e.g. name ACGTGTAGTGCTAGTC ]]> will become name ACGTGTGCTGATGAC ]]> And similarly for Integers, Floats, DateTime, etc. The definition of DateTime will also change, such that it is a primitive, rather than inheriting from String, as it currently does. Eddie has a migration script that will update your mySQL databases automatically. He will make this available on his website (details to follow). Any objections? (don't all yell at once ;-) ) Cheers! Mark -- "Ontologists do it with the edges!" Mark Wilkinson Asst. Professor Dept. of Medical Genetics University of British Columbia PI in Bioinformatics iCAPTURE Centre St. Paul's Hospital Rm. 166, 1081 Burrard St. Vancouver, BC, V6Z 1Y6 tel: 604 682 2344 x62129 fax: 604 806 9274 From mlangill at sfu.ca Tue Oct 18 17:20:29 2005 From: mlangill at sfu.ca (Morgan Langille) Date: Tue Oct 18 18:54:30 2005 Subject: [MOBY-l] Re: [Taverna-users] problems with moby services In-Reply-To: <43556643.4090503@sfu.ca> References: <43556643.4090503@sfu.ca> Message-ID: <4355671D.60100@sfu.ca> Of course I forgot to attach my workflow. So here it is. Morgan Morgan Langille wrote: > This morning I decided try out some of biomoby's new functionality in > taverna (http://www.ebi.ac.uk/~tmo/mygrid/releases/latest/mobyguide/) > . > I followed the guide and I was able to get everything to work (except > for adding a service from within Moby Service Details pop up window). > I then added services that the moby object "DNAsequence" was used as > input for (very cool!). However, when I run the workflow with any > service that takes a DNAsequence it gives errors (2 services give > "denied access to method", 1 service gives "(500) Internal Error > Service"). Is the problem related to the services I am trying or is > this a problem with the moby object? Also, I was wondering why a > DNAsequence object is used in the guide instead of a GenericSequence > object, which the runFasta service uses (although I tested this and it > works with both!)? > > Slighty confused, > > Morgan > > > ------------------------------------------------------------------------ > From mlangill at sfu.ca Tue Oct 18 17:16:51 2005 From: mlangill at sfu.ca (Morgan Langille) Date: Tue Oct 18 18:54:30 2005 Subject: [MOBY-l] problems with moby services Message-ID: <43556643.4090503@sfu.ca> This morning I decided try out some of biomoby's new functionality in taverna (http://www.ebi.ac.uk/~tmo/mygrid/releases/latest/mobyguide/) . I followed the guide and I was able to get everything to work (except for adding a service from within Moby Service Details pop up window). I then added services that the moby object "DNAsequence" was used as input for (very cool!). However, when I run the workflow with any service that takes a DNAsequence it gives errors (2 services give "denied access to method", 1 service gives "(500) Internal Error Service"). Is the problem related to the services I am trying or is this a problem with the moby object? Also, I was wondering why a DNAsequence object is used in the guide instead of a GenericSequence object, which the runFasta service uses (although I tested this and it works with both!)? Slighty confused, Morgan From silvia77 at dist.unige.it Tue Oct 18 04:06:13 2005 From: silvia77 at dist.unige.it (scaglione) Date: Tue Oct 18 18:54:53 2005 Subject: [MOBY-l] Error in BIOMOBY Message-ID: <1129622773.4354acf5262c5@webmail.unige.it> hello, this morning I'cannot reach the biomoby central since an error appears (see attachment). In particular, I've worked in taverna and I tried to "Add new Biomoby scavenger" . What does it mean? Is it a problem related to the central BIOmoby? thanks silvia -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 ----- Fine messaggio inoltrato ----- -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 ----- Fine messaggio inoltrato ----- -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 From edward.kawas at gmail.com Tue Oct 18 18:41:58 2005 From: edward.kawas at gmail.com (Edward Kawas) Date: Tue Oct 18 22:22:28 2005 Subject: [MOBY-l] RE: problems with moby services In-Reply-To: <43556643.4090503@sfu.ca> Message-ID: <000601c5d435$27cdef90$2566a8c0@notebook> Hi Morgan, Those errors are due to the service provider. It may be that the service is no longer running or that the server that houses the service is temporarily offline. Also, there is no problem in running a service that takes a GenericSequence with a DNASequence due to the object hierarchy in Moby. A DNASequence is just a more specialized form of GenericSequence (probably not the best way to put it) and everything that GenericSequence is, DNASequence is also. Eddie > I followed the guide and I was able to get everything to > work (except > for adding a service from within Moby Service Details pop > up window). I > then added services that the moby object "DNAsequence" was > used as input > for (very cool!). However, when I run the workflow with > any service that > takes a DNAsequence it gives errors (2 services give > "denied access to > method", 1 service gives "(500) Internal Error Service"). > Is the problem > related to the services I am trying or is this a problem > with the moby > object? Also, I was wondering why a DNAsequence object is > used in the > guide instead of a GenericSequence object, which the > runFasta service > uses (although I tested this and it works with both!)? > > Slighty confused, > > Morgan From m.rouard at cgiar.org Fri Oct 21 14:09:22 2005 From: m.rouard at cgiar.org (Rouard, Mathieu (INIBAP - Montpellier)) Date: Fri Oct 21 16:51:37 2005 Subject: [MOBY-l] Tags for secondary articles Message-ID: <31AB896A0E7ED211BFBE0008C7283D13DE706C@inibapnt1.inibap.org> Hello, I am looking for some guidelines about the xml tags allowed in secondary articles. Until now, I have found those tags in the documentation datatype default max min enum Is there a tag allowing to describe the paramater? I think it would be helpful when the parameter name (or the value expected) is unclear for the end user of the service. I have another concern about the service deregistration. I would like to update some information about some of my services. Since the deregistration method is deprecated, I believe that the only solution is to remove the RDF file and wait for the agent, right? If so, how long does it take? Is there a way to call it in order to speed up the process? Thanks for your help. Cheers, Mathieu -- Mathieu Rouard IPGRI-INIBAP < www.inibap.org > Parc Scientifique Agropolis II 34397 Montpellier - Cedex 5 - France Tel: +33 (0)467 61 13 02 Fax: +33 (0)467 61 03 34 From senger at ebi.ac.uk Sun Oct 23 13:57:14 2005 From: senger at ebi.ac.uk (Martin Senger) Date: Sun Oct 23 14:11:52 2005 Subject: [MOBY-l] Tags for secondary articles In-Reply-To: <31AB896A0E7ED211BFBE0008C7283D13DE706C@inibapnt1.inibap.org> Message-ID: > I have another concern about the service deregistration. I would like > to update some information about some of my services. Since the > deregistration method is deprecated > [Mark, do you see what I meant that the "deprecation" remark caused confusion?] Mathieu, my understanding (and hope!) is that the deregistration is *not* deprecated. It just can be used only in some circumstances: - Which are none for data types, namespaces and service types, - and for service instances, it can be used only if a service instance was registered without (or with an empty) 'signatureRDF'. > solution is to remove the RDF file and wait for the agent, right? If > so, how long does it take? > Not long, just about a year or so. We all are still waiting for the first agent's visit :-) (of course, unless I missed him; or is it her?) Cheers, Martin -- Martin Senger email: martin.senger@gmail.com skype: martinsenger consulting for: International Rice Research Institute Biometrics and Bioinformatics Unit DAPO BOX 7777, Metro Manila Philippines, phone: +63-2-580-5600 (ext.2324) From maria.mirto at unile.it Tue Oct 25 11:55:07 2005 From: maria.mirto at unile.it (Maria Mirto) Date: Sat Nov 5 10:11:43 2005 Subject: [MOBY-l] CFP: Special Issue FGCS on Life Science Grids for Biomedicine and Bioinformatics Message-ID: <3458.193.204.74.230.1130255707.squirrel@webmail2.unile.it> ************************************************************************* * Call for papers for the Special issue * * * * Life Science Grids for Biomedicine and Bioinformatics * * * * Future Generation Computer System * * Elsevier * * http://www.elsevier.com/inca/publications/misc/lifesciencegrid05.doc * * * ************************************************************************* IMPORTANT DATES Submission for manuscripts: December 15, 2005 Acceptance notification: January 28, 2006 Due date of revised manuscripts: February 28, 2006 Approximate date of publication: Spring, 2006 Purpose of the Special Issue ---------------------------- Omics technologies (genomics - DNA, transcriptomics - RNA, proteomics - protein, metabolomics - metabolite and phenomics ?V phenotype, etc.) and medical informatics have changed the arena of life sciences research forever. They allow generation of data at a large-scale, which started with the whole-genome followed by micro-array gene-expression analysis, mass spectrometry of proteins and metabolites, biomedical imaging processing and health care. Omics technologies require substantial paradigm shifts for the way life sciences research is carried out. Biological experiments are relatively expensive, which forces scientists to focus on advanced design for experimentation as part of a whole-chain research approach. Furthermore, the data generally contains information outside the scope of the original experiment. Hence, to maximize scope of experiments, biological data needs to be reusable, shareable and suitable for in-silico experiments. All of this poses high demands on annotation of data and standardization of data formats. Furthermore, the conversion of data into information and knowledge to support scientists answering biological questions, requires advanced analysis methods and tools that enable mining and integrating these complex datasets. The bottlenecks for life sciences have shifted from data generation to data storage, pre-processing, analysis, and interpretation. The current challenge is to remove these bottlenecks by a combination of life sciences and information technology (IT). The effective and efficient management and use of stored data, and in particular the transformation of these data into information and knowledge, is thus a key requirement for success in Life Sciences, as already has been recognized in many others sectors such as industry, science, government. Life Science Grids are based on the integration of emerging technologies such as Grids, Bioinformatics, Web/Grid Services, Workflow, Semantic Web, to support applications and research in different fields of Life Sciences, such as Health Care, Biomedicine, Computational Chemistry. They promise to provide reliable and secure computing infrastructures facilitating the seamless use of distributed datasets, bioinformatics tools and systems, data mining applications, and knowledge, building a so-called Grid Problem Solving Environment (G-PSE), for solving complex problems in Biomedicine and Health Care. The scope of this special issue is to focus on challenge, applications and services in modern Life Science Grid computing environments. Topics of interest include, but are not limited to the following: - Grid solutions for Life Science applications - Grid infrastructures for bio data analysis - Parallel bio data-intensive applications - Grid infrastructures, middleware and tools for Life Science Grids - Web Services for Life Science Grids - Workflow for Life Science Grids - Semantic Grid for Life Science applications - Bio data analysis and management - Databases and the grid in biomedical field - Data grids for biomedicine and bioinformatics - Data mining of truly large and high-dimensional bio data sets - Security in bio data grids - Biology, Biochemistry and Biomedicine for Grid Environments - Drug Design - Protein Folding - Systems Biology - Genome informatics and phylogeny Guest Editors ------------- Giovanni Aloisio University of Lecce, Italy giovanni.aloisio@unile.it Vincent Breton CNRS/IN2P3, LPC Clermont-Ferrand, France breton@clermont.in2p3.fr Maria Mirto University of Lecce, Italy maria.mirto@unile.it Almerico Murli University of Naples, Italy almerico.murli@dma.unina.it Tony Solomonides University of West of England, UK Tony.Solomonides@uwe.ac.uk Important Dates --------------- Paper submission deadline December 15, 2005 Notification of acceptance January 28, 2006 Camera-ready papers February 28, 2006 Desired publication End of 2006 -- ============================================================ Maria Mirto PhD student, Center for Advanced Computational Technologies via per Monteroni, 73100 Lecce (Le), ITALY S.P.A.C.I. srl ph: +39 0832 297304 fax: +39 0832 297279 ============================================================ From markw at illuminae.com Tue Oct 18 16:49:13 2005 From: markw at illuminae.com (Mark Wilkinson) Date: Tue, 18 Oct 2005 13:49:13 -0700 Subject: [MOBY-l] Migrating MOBY Central to the new object API - MONDAY OCT 24th Message-ID: <1129668553.6798.17.camel@bioinfo.icapture.ubc.ca> Hi all, Eddie and I have been discussing the object ontology migration now that we are not allowing inheritance from primitives. No matter what we do this will break some services, and though I was originally hoping to soften the blow by having a deprecation period, the amount of pain this causes (i.e. everyone having to edit and re-register their services TWICE!) is just inhumane :-) So... I am sure that some of you will cheer this decision, and others will loathe it... we're going to simply migrate the object ontology (in the public MOBY Central here at iCAPTURE) with **no deprecation period at all**. The object names will remain exactly as they are, but will (in some cases) now have different definitions. As such, for those of you running services that are affected by this change, you will only need to update your service code, but NOT need to de/re-register your service. We plan to do this Monday October 24th, so you have a few days to update your services now to reduce the down-time. The way to go about updating your services is as follows: Any XML node that currently has content, but is not a nominal primitive, will now be modified such that it CONTAINS a node that is a primitive, and that primitive will have data content. It's articleName is "content" in every case. e.g. name ACGTGTAGTGCTAGTC ]]> will become name ACGTGTGCTGATGAC ]]> And similarly for Integers, Floats, DateTime, etc. The definition of DateTime will also change, such that it is a primitive, rather than inheriting from String, as it currently does. Eddie has a migration script that will update your mySQL databases automatically. He will make this available on his website (details to follow). Any objections? (don't all yell at once ;-) ) Cheers! Mark -- "Ontologists do it with the edges!" Mark Wilkinson Asst. Professor Dept. of Medical Genetics University of British Columbia PI in Bioinformatics iCAPTURE Centre St. Paul's Hospital Rm. 166, 1081 Burrard St. Vancouver, BC, V6Z 1Y6 tel: 604 682 2344 x62129 fax: 604 806 9274 From mlangill at sfu.ca Tue Oct 18 17:20:29 2005 From: mlangill at sfu.ca (Morgan Langille) Date: Tue, 18 Oct 2005 14:20:29 -0700 Subject: [MOBY-l] Re: [Taverna-users] problems with moby services In-Reply-To: <43556643.4090503@sfu.ca> References: <43556643.4090503@sfu.ca> Message-ID: <4355671D.60100@sfu.ca> Of course I forgot to attach my workflow. So here it is. Morgan Morgan Langille wrote: > This morning I decided try out some of biomoby's new functionality in > taverna (http://www.ebi.ac.uk/~tmo/mygrid/releases/latest/mobyguide/) > . > I followed the guide and I was able to get everything to work (except > for adding a service from within Moby Service Details pop up window). > I then added services that the moby object "DNAsequence" was used as > input for (very cool!). However, when I run the workflow with any > service that takes a DNAsequence it gives errors (2 services give > "denied access to method", 1 service gives "(500) Internal Error > Service"). Is the problem related to the services I am trying or is > this a problem with the moby object? Also, I was wondering why a > DNAsequence object is used in the guide instead of a GenericSequence > object, which the runFasta service uses (although I tested this and it > works with both!)? > > Slighty confused, > > Morgan > > > ------------------------------------------------------------------------ > From mlangill at sfu.ca Tue Oct 18 17:16:51 2005 From: mlangill at sfu.ca (Morgan Langille) Date: Tue, 18 Oct 2005 14:16:51 -0700 Subject: [MOBY-l] problems with moby services Message-ID: <43556643.4090503@sfu.ca> This morning I decided try out some of biomoby's new functionality in taverna (http://www.ebi.ac.uk/~tmo/mygrid/releases/latest/mobyguide/) . I followed the guide and I was able to get everything to work (except for adding a service from within Moby Service Details pop up window). I then added services that the moby object "DNAsequence" was used as input for (very cool!). However, when I run the workflow with any service that takes a DNAsequence it gives errors (2 services give "denied access to method", 1 service gives "(500) Internal Error Service"). Is the problem related to the services I am trying or is this a problem with the moby object? Also, I was wondering why a DNAsequence object is used in the guide instead of a GenericSequence object, which the runFasta service uses (although I tested this and it works with both!)? Slighty confused, Morgan From silvia77 at dist.unige.it Tue Oct 18 04:06:13 2005 From: silvia77 at dist.unige.it (scaglione) Date: Tue, 18 Oct 2005 10:06:13 +0200 Subject: [MOBY-l] Error in BIOMOBY Message-ID: <1129622773.4354acf5262c5@webmail.unige.it> hello, this morning I'cannot reach the biomoby central since an error appears (see attachment). In particular, I've worked in taverna and I tried to "Add new Biomoby scavenger" . What does it mean? Is it a problem related to the central BIOmoby? thanks silvia -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 ----- Fine messaggio inoltrato ----- -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 ----- Fine messaggio inoltrato ----- -- PhD. Silvia Scaglione DIST University of Genoa Viale Causa,13 16145 Genoa phone +39 010 353 2789 phone CBA +39 010 5737 505 fax +39 010 5737 505 From edward.kawas at gmail.com Tue Oct 18 18:41:58 2005 From: edward.kawas at gmail.com (Edward Kawas) Date: Tue, 18 Oct 2005 15:41:58 -0700 Subject: [MOBY-l] RE: problems with moby services In-Reply-To: <43556643.4090503@sfu.ca> Message-ID: <000601c5d435$27cdef90$2566a8c0@notebook> Hi Morgan, Those errors are due to the service provider. It may be that the service is no longer running or that the server that houses the service is temporarily offline. Also, there is no problem in running a service that takes a GenericSequence with a DNASequence due to the object hierarchy in Moby. A DNASequence is just a more specialized form of GenericSequence (probably not the best way to put it) and everything that GenericSequence is, DNASequence is also. Eddie > I followed the guide and I was able to get everything to > work (except > for adding a service from within Moby Service Details pop > up window). I > then added services that the moby object "DNAsequence" was > used as input > for (very cool!). However, when I run the workflow with > any service that > takes a DNAsequence it gives errors (2 services give > "denied access to > method", 1 service gives "(500) Internal Error Service"). > Is the problem > related to the services I am trying or is this a problem > with the moby > object? Also, I was wondering why a DNAsequence object is > used in the > guide instead of a GenericSequence object, which the > runFasta service > uses (although I tested this and it works with both!)? > > Slighty confused, > > Morgan From m.rouard at cgiar.org Fri Oct 21 14:09:22 2005 From: m.rouard at cgiar.org (Rouard, Mathieu (INIBAP - Montpellier)) Date: Fri, 21 Oct 2005 11:09:22 -0700 Subject: [MOBY-l] Tags for secondary articles Message-ID: <31AB896A0E7ED211BFBE0008C7283D13DE706C@inibapnt1.inibap.org> Hello, I am looking for some guidelines about the xml tags allowed in secondary articles. Until now, I have found those tags in the documentation datatype default max min enum Is there a tag allowing to describe the paramater? I think it would be helpful when the parameter name (or the value expected) is unclear for the end user of the service. I have another concern about the service deregistration. I would like to update some information about some of my services. Since the deregistration method is deprecated, I believe that the only solution is to remove the RDF file and wait for the agent, right? If so, how long does it take? Is there a way to call it in order to speed up the process? Thanks for your help. Cheers, Mathieu -- Mathieu Rouard IPGRI-INIBAP < www.inibap.org > Parc Scientifique Agropolis II 34397 Montpellier - Cedex 5 - France Tel: +33 (0)467 61 13 02 Fax: +33 (0)467 61 03 34 From senger at ebi.ac.uk Sun Oct 23 13:57:14 2005 From: senger at ebi.ac.uk (Martin Senger) Date: Sun, 23 Oct 2005 18:57:14 +0100 (BST) Subject: [MOBY-l] Tags for secondary articles In-Reply-To: <31AB896A0E7ED211BFBE0008C7283D13DE706C@inibapnt1.inibap.org> Message-ID: > I have another concern about the service deregistration. I would like > to update some information about some of my services. Since the > deregistration method is deprecated > [Mark, do you see what I meant that the "deprecation" remark caused confusion?] Mathieu, my understanding (and hope!) is that the deregistration is *not* deprecated. It just can be used only in some circumstances: - Which are none for data types, namespaces and service types, - and for service instances, it can be used only if a service instance was registered without (or with an empty) 'signatureRDF'. > solution is to remove the RDF file and wait for the agent, right? If > so, how long does it take? > Not long, just about a year or so. We all are still waiting for the first agent's visit :-) (of course, unless I missed him; or is it her?) Cheers, Martin -- Martin Senger email: martin.senger at gmail.com skype: martinsenger consulting for: International Rice Research Institute Biometrics and Bioinformatics Unit DAPO BOX 7777, Metro Manila Philippines, phone: +63-2-580-5600 (ext.2324) From maria.mirto at unile.it Tue Oct 25 11:55:07 2005 From: maria.mirto at unile.it (Maria Mirto) Date: Tue, 25 Oct 2005 17:55:07 +0200 (CEST) Subject: [MOBY-l] CFP: Special Issue FGCS on Life Science Grids for Biomedicine and Bioinformatics Message-ID: <3458.193.204.74.230.1130255707.squirrel@webmail2.unile.it> ************************************************************************* * Call for papers for the Special issue * * * * Life Science Grids for Biomedicine and Bioinformatics * * * * Future Generation Computer System * * Elsevier * * http://www.elsevier.com/inca/publications/misc/lifesciencegrid05.doc * * * ************************************************************************* IMPORTANT DATES Submission for manuscripts: December 15, 2005 Acceptance notification: January 28, 2006 Due date of revised manuscripts: February 28, 2006 Approximate date of publication: Spring, 2006 Purpose of the Special Issue ---------------------------- Omics technologies (genomics - DNA, transcriptomics - RNA, proteomics - protein, metabolomics - metabolite and phenomics ?V phenotype, etc.) and medical informatics have changed the arena of life sciences research forever. They allow generation of data at a large-scale, which started with the whole-genome followed by micro-array gene-expression analysis, mass spectrometry of proteins and metabolites, biomedical imaging processing and health care. Omics technologies require substantial paradigm shifts for the way life sciences research is carried out. Biological experiments are relatively expensive, which forces scientists to focus on advanced design for experimentation as part of a whole-chain research approach. Furthermore, the data generally contains information outside the scope of the original experiment. Hence, to maximize scope of experiments, biological data needs to be reusable, shareable and suitable for in-silico experiments. All of this poses high demands on annotation of data and standardization of data formats. Furthermore, the conversion of data into information and knowledge to support scientists answering biological questions, requires advanced analysis methods and tools that enable mining and integrating these complex datasets. The bottlenecks for life sciences have shifted from data generation to data storage, pre-processing, analysis, and interpretation. The current challenge is to remove these bottlenecks by a combination of life sciences and information technology (IT). The effective and efficient management and use of stored data, and in particular the transformation of these data into information and knowledge, is thus a key requirement for success in Life Sciences, as already has been recognized in many others sectors such as industry, science, government. Life Science Grids are based on the integration of emerging technologies such as Grids, Bioinformatics, Web/Grid Services, Workflow, Semantic Web, to support applications and research in different fields of Life Sciences, such as Health Care, Biomedicine, Computational Chemistry. They promise to provide reliable and secure computing infrastructures facilitating the seamless use of distributed datasets, bioinformatics tools and systems, data mining applications, and knowledge, building a so-called Grid Problem Solving Environment (G-PSE), for solving complex problems in Biomedicine and Health Care. The scope of this special issue is to focus on challenge, applications and services in modern Life Science Grid computing environments. Topics of interest include, but are not limited to the following: - Grid solutions for Life Science applications - Grid infrastructures for bio data analysis - Parallel bio data-intensive applications - Grid infrastructures, middleware and tools for Life Science Grids - Web Services for Life Science Grids - Workflow for Life Science Grids - Semantic Grid for Life Science applications - Bio data analysis and management - Databases and the grid in biomedical field - Data grids for biomedicine and bioinformatics - Data mining of truly large and high-dimensional bio data sets - Security in bio data grids - Biology, Biochemistry and Biomedicine for Grid Environments - Drug Design - Protein Folding - Systems Biology - Genome informatics and phylogeny Guest Editors ------------- Giovanni Aloisio University of Lecce, Italy giovanni.aloisio at unile.it Vincent Breton CNRS/IN2P3, LPC Clermont-Ferrand, France breton at clermont.in2p3.fr Maria Mirto University of Lecce, Italy maria.mirto at unile.it Almerico Murli University of Naples, Italy almerico.murli at dma.unina.it Tony Solomonides University of West of England, UK Tony.Solomonides at uwe.ac.uk Important Dates --------------- Paper submission deadline December 15, 2005 Notification of acceptance January 28, 2006 Camera-ready papers February 28, 2006 Desired publication End of 2006 -- ============================================================ Maria Mirto PhD student, Center for Advanced Computational Technologies via per Monteroni, 73100 Lecce (Le), ITALY S.P.A.C.I. srl ph: +39 0832 297304 fax: +39 0832 297279 ============================================================